EGCG (Epigallocatechin Gallate): Benefits

Epigallocatechin gallate (EGCG) is a unique plant compound that gets a lot of attention for its potential positive impact on health.

It’s thought to reduce inflammation, aid weight loss, and help prevent heart and brain disease.

This article reviews EGCG, including its health benefits and possible side effects.

What is EGCG?

Formally known as epigallocatechin gallate, EGCG is a type of plant-based compound called catechin. Catechins may be further categorized into a larger group of plant compounds known as polyphenols (1Trusted Source).

EGCG and other related catechins act as potent antioxidants that may protect against cellular damage caused by free radicals (1Trusted Source).

Free radicals are highly reactive particles formed in your body that can damage your cells when their numbers get too high. Eating foods high in antioxidants like catechins may help limit free radical damage.

Additionally, research suggests that catechins like EGCG may reduce inflammation and prevent certain chronic conditions, including heart disease, diabetes, and some cancers (1Trusted Source2Trusted Source).

EGCG exists naturally in several plant-based foods but is also available as a dietary supplement usually sold in the form of an extract.

SUMMARY

EGCG is a type of plant compound called catechin. Research suggests that catechins like EGCG may play a role in protecting your cells from damage and preventing disease.

Naturally found in various foods

EGCG is probably best known for its role as the major active compound in green tea.

In fact, the numerous health benefits associated with drinking green tea are typically credited to its EGCG content (1Trusted Source).

Though EGCG is predominantly found in green tea, it also exists in small amounts in other foods, such as (3):

  • Tea: green, white, oolong, and black teas
  • Fruits: cranberries, strawberries, blackberries, kiwis, cherries, pears, peaches, apples, and avocados
  • Nuts: pecans, pistachios, and hazelnuts

While EGCG is the most researched and potent catechin, other types like epicatechin, epigallocatechin, and epicatechin 3-gallate may offer similar benefits. Plus, many of them are more widely available in the food supply (34Trusted Source).

Red wine, dark chocolate, legumes, and most fruit are a few examples of foods that offer a hefty dose of health-promoting catechins (5Trusted Source).

SUMMARY

EGCG is most prevalent in green tea but also found in smaller quantities in other types of tea, fruit, and some nuts. Other health-promoting catechins are plentiful in red wine, dark chocolate, legumes, and most fruit.

May offer powerful health benefits

Test-tube, animal, and a few human studies indicate that EGCG provides numerous health benefits, including reduced inflammation, weight loss, and improved heart and brain health.

Ultimately, more research is needed to better understand how EGCG may be used as a preventative tool or treatment for disease, though current data is promising.

Antioxidant and anti-inflammatory effects

Much of EGCG’s claim to fame comes from its strong antioxidant capacity and potential to reduce stress and inflammation.

Free radicals are highly reactive particles that can cause damage to your cells. Excessive free radical production leads to oxidative stress.

As an antioxidant, EGCG protects your cells from damage associated with oxidative stress and suppresses the activity of pro-inflammatory chemicals produced in your body, such as tumor necrosis factor-alpha (TNF-alpha) (6Trusted Source).

Stress and inflammation are linked to a variety of chronic illnesses, including cancer, diabetes, and heart disease.

Thus, the anti-inflammatory and antioxidant effects of EGCG are thought to be one of the main reasons for its broad disease-preventing applications (1Trusted Source).

Heart health

Research suggests that EGCG in green tea may support heart health by reducing blood pressure, cholesterol, and the accumulation of plaque in blood vessels — all major risk factors for heart disease (7Trusted Source8Trusted Source).

In an 8-week study in 33 people, taking 250 mg of EGCG-containing green tea extract daily resulted in a significant 4.5% reduction of LDL (bad) cholesterol (9Trusted Source).

A separate study in 56 people found significant reductions in blood pressure, cholesterol, and inflammatory markers in those taking a daily dose of 379 mg of green tea extract over 3 months (10Trusted Source).

Though these results are encouraging, more research is needed to better understand how EGCG in green tea may reduce heart disease risk.

Weight loss

EGCG may also promote weight loss, especially when taken alongside the caffeine naturally found in green tea.

Although much of the study results on EGCG’s effect on weight are inconsistent, some long-term observational research noted that consuming about 2 cups (14.7 ounces or 434 ml) of green tea per day was associated with lower body fat and weight (11Trusted Source).

Additional human studies have collectively found that taking 100–460 mg of EGCG together with 80–300 mg of caffeine for at least 12 weeks is linked to significant weight loss and reduction of body fat (12Trusted Source).

Still, changes in weight or body composition are not consistently seen when EGCG is taken without caffeine.

Brain health

Early research suggests that EGCG in green tea may play a role in improving neurological cell function and preventing degenerative brain diseases.

In some studies, EGCG injections significantly improved inflammation, as well as recovery and regeneration of neural cells in mice with spinal cord injuries (13Trusted Source14Trusted Source).

Additionally, multiple observational studies in humans found a link between a higher intake of green tea and a reduced risk of age-related brain decline, as well as Alzheimer’s and Parkinson’s disease. However, the available data is inconsistent (15Trusted Source).

What’s more, it remains unclear whether EGCG specifically or perhaps other chemical components of green tea have these effects.

More research is needed to better understand whether EGCG may effectively prevent or treat degenerative brain diseases in humans.

SUMMARY

EGCG in green tea may offer a variety of health benefits, such as reduced inflammation, weight loss, and the prevention of heart and brain diseases. Still, more research on its effectiveness is needed.

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